![]() 3 Approximately 78% of patients with chronic hoarseness and more than 80% of patients with asthma have symptoms that may be associated with GERD. 1, 2 Individuals with heartburn or regurgitation often present with additional symptoms associated with GERD, such as noncardiac chest pain, dysphagia, dyspepsia, and globus sensation. Between 35% and 70% of those with heartburn seeking medical care demonstrate evidence of esophagitis based on endoscopy. At least 15% of adults in the United States report having heartburn once a week or more. GASTROESOPHAGEAL reflux disease (GERD) is a chronic gastrointestinal condition characterized by heartburn and regurgitation caused by the reflux of acidic gastric contents into the esophagus. In addition, HRQL is significantly impaired in those persons who report frequent GERD symptoms, and HRQL impairment is exacerbated in those who report nocturnal GERD symptoms. Subjects with nocturnal GERD had significantly more pain than those with hypertension and diabetes ( P<.001) and similar pain compared with those with angina and congestive heart failure.Ĭonclusions Nocturnal symptoms are commonly experienced by individuals who report frequent GERD symptoms. ![]() Subjects with nocturnal GERD demonstrated considerable impairment compared with the US general population and chronic disease populations. Subjects reporting nocturnal GERD symptoms were significantly more impaired than subjects reporting nonnocturnal GERD symptoms on both the physical component summary (38.94 vs 41.52 P<.001) and mental component summary (46.78 vs 49.51 P<.001) and all 8 subscales of the SF-36 ( P<.001). Subjects with nonnocturnal GERD had significant decrements on the SF-36 physical and mental component summary scores compared with the US general population. Seventy-four percent of those with frequent GERD symptoms reported nocturnal GERD symptoms. Results The prevalence of frequent GERD was 14%, with an overall prevalence of nocturnal GERD of 10%. The HRQL was assessed using the Medical Outcomes Study Short-Form 36 Health Survey (SF-36). Respondents were classified as controls, subjects with symptomatic nonnocturnal GERD, and subjects with symptomatic nocturnal GERD. Methods A national random-sample telephone survey was conducted to estimate the prevalence of frequent GERD and nocturnal GERD-like symptoms and to assess the relationship between HRQL, GERD, and nocturnal GERD symptoms. The population-based prevalence of symptoms of nocturnal gastroesophageal reflux disease (GERD) and the impact of those symptoms on health-related quality of life (HRQL) have not been established. Shared Decision Making and Communicationīackground Two types of reflux episodes have been identified: upright or daytime and supine or nocturnal.Scientific Discovery and the Future of Medicine. ![]() Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.
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